Grants Search Results

This team has identified a subset of childhood Acute Lymphoblastic Leukemia (ALL) with specific genetic abnormalities in the leukemia cells (Ph-like ALL) that has poor survival. Some Ph-like ALL patients have genetic abnormalities that make their leukemia cells sensitive to a targeted therapy (dasatinib), which has many fewer side effects than chemotherapy. This consortium is using a COG clinical trial to help identify which children should respond to dasatinib, and then will add this targeted therapy to their chemotherapy to try to improve survival. Awarded at the University of Colorado and transferred to the Children's Hospital of Philadelphia. Funds administered by the Children's Hospital of Philadelphia.

This institution is a member of a research consortium which is being funded by St. Baldrick's: COG Targeted Therapy for ALL Consortium. For a description of this project, see the consortium grant made to the lead institution: Children's Hospital of Philadelphia, Philadelphia, PA

This institution is a member of a research consortium which is being funded by St. Baldrick's: COG Targeted Therapy for ALL Consortium. For a description of this project, see the consortium grant made to the lead institution: Children's Hospital of Philadelphia, Philadelphia, PA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: COG Targeted Therapy for ALL Consortium. For a description of this project, see the consortium grant made to the lead institution: Children's Hospital of Philadelphia, Philadelphia, PA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: COG Targeted Therapy for ALL Consortium. For a description of this project, see the consortium grant made to the lead institution: Children's Hospital of Philadelphia, Philadelphia, PA.

This institution is a member of a research consortium which is being funded by St. Baldrick's:COG Targeted Therapy for ALL Consortium. For a description of this project, see the consortium grant made to the lead institution: Children's Hospital of Philadelphia, Philadelphia, PA.

This grant helps provide necessary resources to establish a database to further research to improve the health and quality of life of adolescent cancer survivors.

While most childhood cancer patients no longer die from cancer, young adult survivors of childhood cancer face enormously distressing side effects from their life-saving treatments. These include severe sexual and reproductive problems. Currently, no support is available to help educate young adult survivors about how to manage treatment-related sexual problems and fertility-related distress. This project aims to develop and deliver the first sexual health educational intervention for young adult survivors. This research can make a significantly positive impact on the quality of life for thousands of young adult cancer survivors who are struggling and in need of support.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

Children with cancer can often be successfully treated with chemotherapy drugs that can unfortunately damage the heart in the process. Development of an effective method to prevent this type of injury while curing the cancer is very important. This consortium's goal is to give children successfully cured of cancer the greatest chance of having a completely healthy life afterwards, free of treatment-related side effects. The study is to determine whether a drug called dexrazoxane, which appears to be safe and effective in adults in preventing chemotherapy-related heart injury, can be similarly safe and effective when used in children. Funds administered by Fred Hutchinson Cancer Research Center.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Preventing Heart Injury During Cancer Treatment. For a description of this project, see the consortium grant made to the lead institution: Fred Hutchinson Cancer Research Center, Seattle, WA.

Based on progress to date, Dr. Allen-Rhoades was awarded a new grant in 2014 to fund an optional third year of this fellowship. Osteosarcoma is a bone cancer that affects children, adolescents and young adults. Patients have better survival if the cancer has not spread to other parts of the body. This project aims to develop a blood test that can detect the cancer and determine if it has spread to other areas. This test will be more sensitive and easier to use than current methods, and will ultimately help improve the survival of children with osteosarcoma.

The concept of resilience implies an ability to withstand stress after a significant crisis. While there are several theories of resilience, there is little consensus about how to define it or, more importantly, how to promote it. Cancer in children and adolescents can pose daunting challenges for patients as well as their families. This study explores a novel model of resilience among adolescents and parents of children with cancer. Promoting resilience during and after childhood cancer will promote more positive psychosocial outcomes and ultimately enable better family-level survivorship.

Based on progress to date, Dr. Friedman, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Medulloblastoma, the most common malignant pediatric brain tumor, is a leading cause of cancer-related death. Current treatments are harmful to the developing brain. Brain tumor-initiating cells (BTIC), which give rise to all tumor cells like a queen bee, are likely responsible for cancer recurrence. Genetically-altered herpes simplex virus, which has been used safely and effectively in adult trials, targets and kills tumor cells and BTIC while sparing normal brain cells. This laboratory is studying the use of clinically-ready viruses in difficult-to-treat medulloblastomas, to provide the foundation for future pediatric trials using this cutting-edge therapy to benefit children with these deadly cancers. A portion of the grant was generously supported by the Miracles for Michael Fund, a St. Baldrick's Hero Fund created in memory of Michael Orbany and honors his tremendous strength to never ever give up.