Grants Search Results

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This grant funds a Clinical Research Coordinator and Clinical Research Associate to ensure that more kids can be treated on clinical trials, their best hope for a cure, at this institution.

This grant helped provide necessary resources to ensure that more kids can be treated on clinical trials, their best hope for a cure, at this institution.

This grant helps provide staffing to ensure that more kids can be treated on clinical trials, their best hope for a cure, at this institution.

This grant helps provide necessary resources at this institution to ensure that more kids can be treated on clinical trials, their best hope for a cure.

This grant helps provide necessary resources for the Late Effects/Survivorship Program at this institution to ensure that more kids can be treated on clinical trials, their best hope for a cure.

This grant brings together SIOP's Working Group on Essential Medicines, a group of experts from around the globe, to develop a multi-faceted approach to increase the availability of essential medicines for young people with childhood cancer world-wide.

There are currently over 350,000 childhood cancer survivors in the U.S., but treatments often result in persistent late-occurring health problems. One of the most devastating is congestive heart failure (CHF) resulting from treatment with a class of chemotherapy drugs called anthracyclines. It is estimated that 1 in 10 children treated with high-dose anthracyclines will develop CHF, with 1 in 2 dying within five years of diagnosis of CHF. Studies indicate that a low-dose blood pressure medication called carvedilol may help prevent the onset of CHF. This Consortium for Pediatric Intervention Research conducts a clinical trial with collaboration between five COG-member institutions. The project has the potential to not only improve overall cardiac function, but prevent the likelihood of developing CHF in survivors at highest risk. Funds administered by Beckman Research Institute of the City of Hope. Year two of this grant was generously funded by the Rally Foundation.

While currently 70% of children with brain tumors survive beyond 5-years from diagnosis, radiation to the brain and spine are cornerstones of therapy. The cost of this treatment is impaired neuro-cognitive function, premature heart problems, stroke, and impaired quality of life in many. The role of injury to the heart and vascular system from radiation has not been previously studied in childhood brain tumor survivors. While killing tumor cells, radiation may lead to narrowing and stiffening of the vessels in the brain. Stiffening of the aorta is a progressive with normal aging in the lifespan. This project studies stiffness in the aorta and its relation to flow in the vessels in the brain among children who received radiation therapy, a novel attempt to link the heart and the brain following childhood cancer. 

The treatments used to cure pediatric cancers can cause infertility. Banking sperm at diagnosis is the gold standard for preserving fertility for boys who have reached puberty, but is not an option for younger boys who do not yet have mature sperm in their testicles. The prepubertal testicle does contain a small number of stem (parent) cells that will eventually become mature sperm, so one new idea is the use of testicular tissue frozen at diagnosis, then later thawed with the parent cells reimplanted into the testis to mature or matured outside the body and then used with assistive reproductive techniques. This consortium is collecting testicular tissue samples to increase the amount of tissue available for research, in the hope of providing an option for fertility preservation to patients who currently have no options at all.  Funds administered by the Children's Hospital of Philadelphia.

Adolescents with cancer experience many symptoms resulting from their disease and its treatment. Recognizing and managing these contributes to improved quality of life during treatment and on into survivorship. This study uses an approach that allows adolescents to identify clusters describing their symptom experience from their perspective. The purpose is to develop and test the use of a computer-based tool exploring symptom clusters among adolescents with cancer. The goal of these findings is to provide data to support use of the tool in a larger group of adolescents and to enhance communication between them and healthcare providers.

Transfusions with packed red blood cells (PRBCs) are commonly used when children treated for cancer develop anemia (low red blood cell count). PRBC transfusions carry iron that can be deposited in various body tissues, such as the heart. The body cannot remove this iron overload by itself, and if it stays in the heart, it can cause damage (cardiomyopathy). At this time, we do not know how often patients have extra iron in their heart after PRBC transfusions. This study uses a magnetic resonance image (MRI) test that can measure iron and learn about other things that might affect the heart, such as anthracycline chemotherapy and what effect iron-related cardiomyopathy has on daily life. The overall goal is to increase the length and quality of survival for people successfully treated for cancer during childhood.

Research in the last 30 years has had a wonderful impact on the survival rate of kids with many types of cancers. However, aggressive treatment regimens on children's young bodies have many negative side effects. One class of chemotherapy drugs, anthracyclines, have been used to effectively treat more than 135,000 childhood cancer survivors, but cause significant risk for cardiovascular disease by the time these children reach their 30s. This research will use Cardiac Magnetic Resonance Imaging and chemical markers in the blood to identify heart damage caused by anthracyclines before symptoms begin, thereby reducing long-term life-threatening heart conditions for pediatric cancer survivors.

Based on progress to date, Dr. Wolfson was awarded a new grant in 2014 to fund an additional two years of this Scholar award. Cancer treatments for young children and older adults have made incredible progress. However, adolescents and young adults (AYAs) diagnosed at 15 to 39 years old have not seen these same improvements, leaving an AYA Gap. Within this AYA group, racial/ethnic minority patients fare poorly, as do patients not receiving care at a nationally recognized cancer center. This study tests the theory that the AYA Gap is largely due to disparities in access to quality cancer care. Ultimately, the aim of this project is to help develop strategies to reduce these disparities in outcome and eliminate the AYA Gap. Awarded at the City of Hope and transferred to University of Alabama at Birmingham.

This institution is a member of a research consortium which is being funded by St. Baldrick"s: the Testicular Cryopreservation Consortium (TCC). For a description of this project, "Translating the Science of Testicular Tissue Cryopreservation," see the consortium grant made to the lead institution: the Children's Hospital of Philadelphia, Philadelphia, PA.

This institution is a member of a research consortium which is being funded by St. Baldrick"s: the Testicular Cryopreservation Consortium (TCC). For a description of this project, "Translating the Science of Testicular Tissue Cryopreservation," see the consortium grant made to the lead institution: the Children's Hospital of Philadelphia, Philadelphia, PA.

This institution is a member of a research consortium which is being funded by St. Baldrick's: the Consortium for Pediatric Intervention Research. For a description of this project, "Pharmacologic prevention of heart failure in survivors of childhood cancer," see the consortium grant made to the lead institution: the Beckman Research Institute of the City of Hope, Duarte, CA. Year two of this grant was generously funded by the Rally Foundation.

This institution is a member of a research consortium which is being funded by St. Baldrick's: the Consortium for Pediatric Intervention Research. For a description of this project, "Pharmacologic prevention of heart failure in survivors of childhood cancer," see the consortium grant made to the lead institution: the Beckman Research Institute of the City of Hope, Duarte, CA. Year two of this grant was generously funded by the Rally Foundation.