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Children and adolescents with cancer and their families are at increased risk for psychosocial problems that can contribute to poorer health and quality of life, and it has been recommended that pediatric cancer centers develop programs to screen patients and families for psychosocial risk. The majority of pediatric cancers centers do not have practices in place to effectively and routinely screen all patients and families for psychosocial difficulties, with time and resources being acknowledged as barriers to implementation. Dr. Gilleland Marchak is developing a novel, patient-friendly technology to screen for psychosocial risk and evaluating its use at a large pediatric cancer center. Study outcomes will include data related to feasibility and acceptability of electronic screening, as well as efficacy in identifying families in distress and connecting them with family support team members to address problems in real time. By successfully leveraging technology to reduce barriers to universal psychosocial screening, we can improve communication between oncology providers and families regarding critical mental health, neurocognitive, and social issues that may negatively impact pediatric cancer treatment and health outcomes.

The survival rates of pediatric cancers have dramatically improved over the past 40 years due to aggressive treatment regimens, which have side effects. Anthracyclines are one class of chemotherapy drugs that have been used to treat more than 190,000 childhood cancer survivors but cause risk of cardiovascular disease. Connecticut Children's team of oncologists, cardiologists and endocrinologists has developed a clinical practice guidelines to prevent and recognize early cardiovascular disease in pediatric cancer survivors. Dr. Orsey is testing their scoring system among childhood cancer patients from a database and in the clinic. She anticipates that the scoring system will allow doctors to standardize the way they treat patients so that cardiovascular disease is prevented or recognized and treated early in order to decrease heart disease in childhood cancer survivors.

Cancer-related pain greatly compromises quality of life, and can increase disease morbidity, mortality, and healthcare costs by reducing children's compliance to medical procedures. The burden of cancer-related pain does not end when treatment concludes: many survivors of childhood cancer report cancer-related pain well into adulthood. Thus, there is a critical need for interventions that can reduce pain during and after children's treatments for cancer. Dr. Marusak is testing whether a martial arts therapy that centers around mindful breathing and meditative techniques can reduce pain and the underlying brain mechanisms in young cancer patients and survivors.

Children treated for leukemia often have difficulty with school and learning. These children are also known to report sleep disturbances. With the MaxLove Project Fund St. Baldrick's Supportive Care Research Grant, Dr. Ruble is measuring sleep with a home monitor, and testing survivors for specific learning difficulties. She will then examine the relationship between sleep and cognitive function in this population. Dr. Ruble hopes in the future that this will allow researchers to design treatments for sleep disturbances that will ultimately help with learning and school. The MaxLove Project Fund honors the survivorship journey of Max Wilford who was diagnosed with a brain stem tumor at the age of four. Despite several surgeries and an intense treatment protocol, Max is now able to be a “regular” kid due in large part to integrative therapies he received.

This grant supports a Nurse Coordinator who works with new patients in the combined Adolescent and Young Adult and Cancer Survivor Clinic. The Nurse Coordinator also works as a guide throughout the process of scheduling visits, and provides information and resources throughout the time that the patients attend the Clinic.

This grant supports research staff who are developing a Transition Clinic for Adolescents and Young Adults. The grant also supports a Nurse Educator who is dedicated to aiding pediatric and teenage cancer survivors in successfully transitioning to adult health care services.

This grant supports a Data Manager who organizes medical records and enrolls past patients into the Passport for Care program, which gives childhood cancer survivors crucial access to their medical information and healthcare guidelines, so that they can transition from pediatric healthcare providers into the adult survivorship program.

This grant supports a pediatric psychologist, nutritionist, and physical therapist who work together to evaluate and treat childhood cancer survivors during regularly scheduled long-term survivorship appointments.

This grant supports construction of a REDCap database that will capture valuable clinical information on demographics, diagnosis, and treatment information for adolescent and young adult (AYA) cancer patients. The grant also supports a Patient Care Navigator who maintains the REDcap database and works to coordinate resources with other departments. This database helps track patients over time, giving more information to researchers and providing better long-term care for childhood cancer survivors.

This grant funds a Nurse Practitioner who enrolls and provides services for patients in the Childhood Cancer Survivorship Program. The program also provides critical patient data for survivorship researchers.

Young age at diagnosis and intense therapy result in multiple late effects for Neuroblastoma survivors. The majority of High-Risk Neuroblastoma HR-NBL survivors have striking growth failure. Dr. Mostoufi-Moab is investigating the mechanism of growth failure in high-risk neuroblastoma survivors. Dr. Mostoufi-Moab is employing state-of-the art imaging measures of the growth plate to study and understand the mechanism of growth failure in high-risk neuroblastoma survivors, and target future intervention trials.

Childhood cancer survivors can have problems with their lungs due to their cancer treatment. Dr. Kirchhoff is completing the first study to examine how air pollution affects the health of childhood cancer survivors.

This grant funds research personnel to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a dedicated Adolescent and Young Adult (AYA) cancer survivorship program at Ochsner, to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant helps provide necessary resources for the Childhood Cancer Survivorship Program at this institution. The program provides survivors the support, treatment and education they need to prevent and address these late effects.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL